Glossary

Term · Before Pregnancy

varicocele

Also: varicocele vein, enlarged scrotal veins, varicose veins of the testicle

Enlarged veins inside the scrotum, above a testicle. A common, often silent cause of male factor infertility that a doctor may check.

In plain words

A varicocele is a cluster of enlarged veins in the scrotum, usually on the left side. It is common in men, and many have no symptoms. It is found most often during tests for . A varicocele can affect by warming the testicle and changing blood flow. Some men feel a dull ache or heaviness. Repair is an option for some men with abnormal semen results and a clinical varicocele. The benefit for pregnancy rates is debated, and the decision is made with a urologist or fertility specialist.

The deeper version

Varicocele is of the pampiniform plexus, found in about 15 percent of adult men and in a higher share of men evaluated for infertility. Proposed mechanisms include testicular hyperthermia, hypoxia, of toxic metabolites, and altered Leydig function. The AUA and ASRM male infertility guideline (2020) recommends varicocelectomy for men with a clinical varicocele and abnormal semen parameters in the context of infertility, and advises against repair of subclinical varicocele in men without abnormal semen parameters. Pregnancy benefit from repair is debated: randomized trials show variable effects on sperm parameters and inconsistent improvement in live birth rates. The WHO laboratory manual (2010) sets the semen reference values used to judge abnormality.

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Sources

  • American Urological Association and American Society for Reproductive Medicine — Male Infertility: AUA/ASRM Guideline, 2020
  • World Health Organization — WHO Laboratory Manual for the Examination and Processing of Human Semen, 5th edition, 2010
  • American Society for Reproductive Medicine — Varicocele and male infertility: a committee opinion, 2014

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