Glossary

Term · Feeding Your Baby

melatonin

Also: sleep hormone, pineal hormone

A hormone that signals night to the body and helps set the sleep-wake rhythm. It is also found in human milk, and levels there change across the day.

In plain words

Melatonin is a hormone the brain makes in response to darkness. It helps set the body's sleep and wake clock. A baby's own melatonin rhythm develops over the first few months, which is one reason days and nights can feel mixed up. Melatonin also passes into breast milk, and levels there tend to be higher at night. Researchers study it as one of several sleep-related compounds in milk. Melatonin is also sold as a supplement for adults. Whether it has any role for babies or in pregnancy is a question for your provider. Its role in milk is still being studied.

The deeper version

Melatonin is synthesized from serotonin in the pineal gland, with secretion driven by the suprachiasmatic nucleus and suppressed by light. Infant secretion becomes entrained to a pattern over the first months of life. Human milk contains melatonin with a nocturnal peak. Italianer and colleagues (Nutrients, 2020) reviewed circadian variation in milk composition, including melatonin, tryptophan, and cortisol, which is highest in morning milk. The clinical relevance of milk melatonin to infant sleep is not established. Melatonin is used in some pediatric and neurodevelopmental settings, and its use in pregnancy and infancy outside those settings is not established. The controversy is whether milk melatonin has a meaningful physiological effect on the infant.

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Sources

  • Italianer MF and colleagues — Circadian variation in human milk composition, a systematic review, Nutrients (2020)

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