Glossary

Term · Pregnancy: Mind and Life

hippocampus

Also: hippocampi, memory center of the brain

A curved structure deep in the brain that helps form new memories and learning. In pregnancy, it comes up in research on how nutrients such as choline may shape a baby's developing brain.

In plain words

The hippocampus is a seahorse-shaped part of the brain, one on each side, deep in the temporal lobe. It helps turn experiences into lasting memories and supports learning and finding your way around. It keeps developing before birth and in the early years. That is why it comes up in pregnancy research on nutrition. Some rodent studies have tied prenatal to changes in how the hippocampus forms and works, and those changes lasted into old age. The research is in animals, so it does not show what the same food does for human babies. The hippocampus is also not the same as the memory lapses many mothers describe after birth. Those are often linked to sleep loss, stress, or mood. The word names a structure, not a condition.

The deeper version

The hippocampus is a bilateral limbic structure in the medial temporal lobe, with dentate gyrus, CA fields, and subiculum. It is central to episodic and spatial memory and to pattern separation. Neurogenesis in the dentate gyrus continues into adulthood. Cholinergic input from the septum, supplied by acetylcholine derived from dietary choline, shapes its development. Meck and Williams (2003, Neuroscience and Biobehavioral Reviews) reported that prenatal choline in rodents altered hippocampal neuron size, dendritic branching, and memory performance into old age. Human trials linking prenatal choline to child memory are fewer and smaller. Whether the rodent effects translate to people at intakes reachable through food remains an open question.

Where it comes up

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Sources

  • Meck WH, Williams CL — Metabolic imprinting of choline by its availability during gestation: implications for memory and attentional processing across the lifespan. Neuroscience and Biobehavioral Reviews, 2003

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