Pregnancy: Your Body

Pregnancy: Your Body

Rh factor and RhoGAM

If you are Rh negative, a RhoGAM shot around 28 weeks and after birth keeps your body from reacting to a baby with Rh positive blood.

General research · seeking a stewardpregnancyAlso searched as: Rh negative, RhoGAM shot, antibody screen

What it is

Rh negative, a RhoGAM shot, an antibody screen: these come up at the first blood draw. Rh is a protein on red blood cells. About 15 in 100 people lack it. If you are negative and the baby is positive, and some of the baby's blood crosses into yours, your body can make antibodies that harm later Rh positive babies. RhoGAM, a shot of ready-made antibodies, stops your body from making its own.

What's typical

Your blood type and an antibody screen are checked at the first visit. If you are Rh negative, a RhoGAM shot is given around 28 weeks. If the baby is positive, you get a second shot within 72 hours of birth. You also get one after any bleeding, a fall, or a miscarriage.

What's known

ACOG recommends RhoGAM for all unsensitized Rh negative mothers at 28 weeks and after birth of an Rh positive baby. The shot has been used since 1968, and the disease it guards against is now rare.

What helps

  • Keep a card or phone note that says you are Rh negative, for any ER visit in pregnancy.
  • After any bleeding or a hard fall, call and mention your Rh status. The window for the shot is 72 hours.
  • Ask whether your practice can test the baby's Rh type from your blood.

When to call someone

  • Nowany vaginal bleeding, a car accident, or a hard fall on your belly.
  • Todayyou are past 28 weeks and have not had the shot, or you gave birth and no one has mentioned it.
  • At your next visitquestions about your antibody screen result.

Who helps

OB-GYNMidwife

Tools: Due Date Calculator

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Sources

  • American College of Obstetricians and Gynecologists — Practice bulletin on prevention of Rh D alloimmunization
  • NHS — Rhesus disease: prevention

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