Glossary

Term · Pregnancy: Your Body

RhoGAM

Also: Rho GAM, RhoGAM shot

Another name for Rh immune globulin, the Rh shot. RhoGAM is a brand name used in the United States. See Rh immune globulin.

In plain words

RhoGAM is a brand name for a product in the family, often called the Rh shot. It belongs to the same class of medicine as Rh immune globulin, and its uses are the same. It is given to Rh-negative people in certain pregnancy and postpartum situations to lower the chance of antibodies against Rh-positive blood. Other brands and forms exist. The shot is given as an injection, and the timing depends on your pregnancy history and your baby's blood type. Ask your provider which product your birth or care team uses, and whether it applies to you. The reasons for the shot and the full picture are under the Rh immune globulin entry.

The deeper version

RhoGAM (Rho(D) immune globulin, human) is a branded, plasma-derived preparation approved in the United States for use in D-negative individuals. It belongs to the same class as other Rh D immune globulin products, and clinicians choose among products by availability and local protocol. The product labeling describes its indications, which include antenatal and postpartum prophylaxis and use after pregnancy losses and procedures, along with safety warnings the label sets out. Evidence that brands differ in clinical outcome is not established. Controversy about thresholds for administration applies to the class rather than to this brand, and the product labeling sets out the full indications and safety text.

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Sources

  • U.S. Food and Drug Administration — RhoGAM (Rho(D) Immune Globulin, Human) prescribing information
  • American College of Obstetricians and Gynecologists — Practice Bulletin No. 181: Prevention of Rh D Alloimmunization (2017)

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