Glossary

Term · Feeding Your Baby

necrotizing enterocolitis

Also: NEC, necrotizing enterocolitis of the newborn

A serious inflammation and injury of the bowel that mostly affects premature babies. Human milk is linked with lower risk.

In plain words

Necrotizing enterocolitis, or NEC, is a serious illness of the intestine. The bowel becomes inflamed, and parts of it can be damaged. It mostly affects premature babies, and it can happen less often in full-term babies. Doctors do not know the cause in every case. It is more likely in very small babies and in babies who are very sick. Human milk is linked with lower risk, and many NICUs use it for babies in their care. Signs can include a swollen belly, vomiting, blood in the stool, or a baby who looks unwell. These need immediate medical care, so call your baby's team right away.

The deeper version

Necrotizing enterocolitis is an acute inflammatory injury of the intestinal wall, most often in preterm infants. Its pathogenesis combines reduced motility, an immature mucosal barrier, dysregulated inflammation, and bacterial colonization leading to ischemia. The protective effect of human milk is attributed to , oligosaccharides that shape the microbiome, , and growth factors (Neu and Walker, New England Journal of Medicine, 2011). Diagnosis uses clinical signs and radiographs showing pneumatosis intestinalis, portal venous gas, or free air, with staging by modified Bell criteria. The AAP policy on breastfeeding and human milk (Eidelman and Schanler, 2012) supports when mother's milk is unavailable for high-risk infants. The controversy concerns feeding advancement speed, use, and whether donor milk changes outcomes beyond human milk.

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Sources

  • Neu J and Walker WA — Necrotizing enterocolitis, New England Journal of Medicine (2011)
  • Eidelman AI and Schanler RJ, American Academy of Pediatrics — Breastfeeding and the use of human milk, policy statement (2012)

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