Glossary

Term · Pregnancy: Your Body

intravenous iron

Also: IV iron, iron infusion

Iron given directly into a vein in a clinic or hospital, used when iron deficiency anemia is severe or oral iron does not work well. It is given by a clinician.

In plain words

Intravenous iron is iron given through a vein, usually as an infusion over minutes to hours at a clinic or hospital. It is used when is moderate or severe, which is common in pregnancy and after birth. Some people cannot take iron pills well because of stomach upset, or their body does not absorb them well. In those cases, a clinician may consider IV iron. Guidance has shifted toward using to diagnose , and toward using IV iron more often. Side effects can include reactions during the infusion, so the team usually watches you while it runs. Iron levels are rechecked after treatment. Ask your provider whether IV iron is an option for your levels and your history.

The deeper version

Intravenous iron formulations bypass gut absorption and deliver iron directly to the reticuloendothelial system and marrow. In pregnancy, IV iron is considered for moderate to severe anemia, for intolerance or failure of oral iron, and in the third trimester when time is short. ACOG Practice Bulletin 233 (2021) updated US guidance toward ferritin-based diagnosis and broader use of intravenous iron. Trials in pregnancy have reported higher and fewer transfusions than oral iron in some settings, though the evidence for maternal and infant outcomes is still developing. Controversy persists over diagnostic thresholds and over how to balance cost and access against oral therapy.

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Sources

  • American College of Obstetricians and Gynecologists — Practice Bulletin 233: Anemia in Pregnancy, 2021

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