Glossary

Term · Before Pregnancy

dysbiosis

Also: gut dysbiosis, microbiome imbalance, gut imbalance

A change in the balance of bacteria in the gut or another body site. Pregnancy shifts the gut microbiome, and researchers study how such shifts relate to health.

In plain words

Dysbiosis means an imbalance in the community of microbes that live in the body, most often the gut. Pregnancy changes that community. Researchers have found shifts in gut bacteria across pregnancy, and they are studying whether some shifts relate to diabetes, high blood pressure, or digestive symptoms. The word is used more in research than in daily care. Constipation, bloating, and changes in digestion are common in pregnancy and have many causes. The science is still developing, and the evidence does not yet show what a healthy balance looks like for each person. Ongoing digestive symptoms are worth raising with a provider. use in pregnancy is discussed with a provider, since evidence on benefit is mixed.

The deeper version

Dysbiosis is a disruption of microbial community structure and function relative to a healthy reference, though no universal definition exists. Petersen and Round (Cellular Microbiology, 2014) argue for a definition tied to functional consequences for host immunity and disease. Koren and colleagues (Cell, 2012) documented progressive shifts in gut microbiota across pregnancy, with changes in diversity and taxa linked to metabolic adaptation. Clinical interest centers on whether dysbiosis contributes to and , whether probiotic benefits mother or infant, and how to manage the functional gastrointestinal symptoms, chiefly constipation, that pregnancy physiology produces. Causal evidence from humans is limited, and most data are observational.

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Sources

  • Koren O et al. — Host remodeling of the gut microbiome and metabolic changes during pregnancy. Cell, 2012
  • Petersen C, Round JL — Defining dysbiosis and its influence on host immunity and disease. Cellular Microbiology, 2014

The Mothership Topic Wiki is general information for mothers and the people who care for them. It is not medical, legal, or mental-health advice and does not create a provider relationship. Experiences posted by members are their own. In an emergency call 911. If you are having thoughts of harming yourself, call or text 988.